24 research outputs found

    ΠžΡ€Π³Π°Π½Ρ–Π·Π°Ρ†Ρ–Ρ Π±ΡƒΡ…Π³Π°Π»Ρ‚Π΅Ρ€ΡΡŒΠΊΠΎΠ³ΠΎ ΠΎΠ±Π»Ρ–ΠΊΡƒ Ρƒ суб'Ρ”ΠΊΡ‚Ρ–Π² ΠΌΠ°Π»ΠΎΠ³ΠΎ ΠΏΡ–Π΄ΠΏΡ€ΠΈΡ”ΠΌΠ½ΠΈΡ†Ρ‚Π²Π°

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    Along with continuing changes in the tax law, the requirements to the organization of small business accounting are changing, too. The article provides the analysis of normative legal documents governing small business accounting. The accounting requirements for small businesses of general and simplified tax accounts have been systematized. The necessity and essentiality of drawing primary documents has been grounded. The list and order of making tax registers and preparation of financial statements according to the chosen form of accounting organization have been considered

    ΠžΡ€Π³Π°Π½Ρ–Π·Π°Ρ†Ρ–Ρ Π±ΡƒΡ…Π³Π°Π»Ρ‚Π΅Ρ€ΡΡŒΠΊΠΎΠ³ΠΎ ΠΎΠ±Π»Ρ–ΠΊΡƒ Ρƒ суб'Ρ”ΠΊΡ‚Ρ–Π² ΠΌΠ°Π»ΠΎΠ³ΠΎ ΠΏΡ–Π΄ΠΏΡ€ΠΈΡ”ΠΌΠ½ΠΈΡ†Ρ‚Π²Π°

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    Along with continuing changes in the tax law, the requirements to the organization of small business accounting are changing, too. The article provides the analysis of normative legal documents governing small business accounting. The accounting requirements for small businesses of general and simplified tax accounts have been systematized. The necessity and essentiality of drawing primary documents has been grounded. The list and order of making tax registers and preparation of financial statements according to the chosen form of accounting organization have been considered

    Visualization as a method of overcoming anxiety and nervous tension, reducing symptoms of depression and stress in difficult life situation

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    The problem of overcoming anxiety and nervous tension has turned out to be one of the most pressing in the modern world, which has found itself in an unprecedented situation of uncertainty and instability. Like many other significant negative processes on a global scale, it provoked an increase in people’s anxiety levels. A person’s uncertainty about tomorrow, without the opportunity to live a normal way of life, has created the preconditions for the occurrence of excessive emotional reactions to ongoing events, a decrease in performance and the perception of the surrounding world or many objects within it as potentially dangerous or stressful. The study showed that adaptive coping strategies are interconnected with the processes of self-knowledge, revaluation of values and positive self-attitude, visualization bei8ng one of them.These coping strategies include the use of visualization techniques in situations that are accompanied by anxiety, nervous tension, stress and depression. The relevance of this study lies in the fact that in the era of instability and uncertainty, people experience stress much more often. This technique can not only help cheer up, but also help improve well-being. Anxiety causes fear; sudden mood swings; tearfulness; irritability; persistently low mood, gloomy forebodings

    Arquivar atividades em termos de autenticidade de documentos eletrônicos e variação do número de cópias

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    The article is devoted to the problems of archive activity during the digital era, which are conditioned from the authors' point of view by the introduction of electronic documents that have changed the content of paperwork and archiving key categories - authenticity and copy number variation, as well as related originality and authenticity. The technologies of work in the archive, always considered as a unique system of originals are based on the traditional understanding of these categories. Using the method of expert assessments during the determination of key category content, the authors conclude that the current activity of the archives is aimed at copy production activity increase, their management and the provision of authenticity, reliability, integrity and suitability for use. Nowadays the issue of document archiving requires the consolidation of state and non-state structure efforts to develop a new attitude to the authenticity of electronic documents, to change the usual nature of archival institution interaction with users and interested citizens, state authorities and administration, law enforcement and judicial system.El artículo estÑ dedicado a los problemas de la actividad de archivo durante la era digital, que estÑn condicionados desde el punto de vista de los autores por la introducción de documentos electrónicos que han cambiado el contenido del papeleo y las categorías clave de archivo: autenticidad y variación del número de copias, como así como la originalidad y autenticidad relacionadas. Las tecnologías de trabajo en el archivo, siempre consideradas como un sistema único de originales, se basan en el entendimiento tradicional de estas categorías. Usando el método de evaluaciones de expertos durante la determinación del contenido de la categoría clave, los autores concluyen que la actividad actual de los archivos estÑ dirigida a aumentar la actividad de producción de copias, su gestión y la provisión de autenticidad, confiabilidad, integridad y adecuación para su uso. Hoy en día, el tema del archivo de documentos requiere la consolidación de los esfuerzos de la estructura estatal y no estatal para desarrollar una nueva actitud hacia la autenticidad de los documentos electrónicos, para cambiar la naturaleza habitual de la interacción de la institución archivística con los usuarios y ciudadanos interesados, las autoridades estatales, la administración y la ley.O artigo é dedicado aos problemas da atividade de arquivo durante a era digital, eles são condicionados a partir do ponto de vista dos autores para a introdução de documentos eletrônicos que mudaram o conteúdo de documentos e categorias de arquivos-chave: autenticidade e variação do número de cópias, bem como a originalidade e autenticidade relacionadas. Tecnologias de trabalho no arquivo, sempre considerado como um único sistema original, com base no entendimento tradicional destas categorias. Usando o método de avaliaçáes de peritos para a determinação da categoria-chave, os autores concluem que a atividade de arquivos atual visa aumentar cópias atividade de produção, gestão e prestação de autenticidade, confiabilidade, integridade e adequação para uso. Hoje, a questão do arquivamento de documentos requer a consolidação dos esforços de estruturas estatais e não-estatais para desenvolver uma nova atitude em relação à autenticidade dos documentos eletrônicos, para mudar a natureza habitual da interação da instituição de arquivo utilizadores e cidadãos interessados, autoridades estatais, administração e direito

    Controlling local thermalization dynamics in a Floquet-engineered dipolar ensemble

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    Understanding the microscopic mechanisms of thermalization in closed quantum systems is among the key challenges in modern quantum many-body physics. We demonstrate a method to probe local thermalization in a large-scale many-body system by exploiting its inherent disorder, and use this to uncover the thermalization mechanisms in a three-dimensional, dipolar-interacting spin system with tunable interactions. Utilizing advanced Hamiltonian engineering techniques to explore a range of spin Hamiltonians, we observe a striking change in the characteristic shape and timescale of local correlation decay as we vary the engineered exchange anisotropy. We show that these observations originate from the system's intrinsic many-body dynamics and reveal the signatures of conservation laws within localized clusters of spins, which do not readily manifest using global probes. Our method provides an exquisite lens into the tunable nature of local thermalization dynamics, and enables detailed studies of scrambling, thermalization and hydrodynamics in strongly-interacting quantum systems.Comment: 6 pages, 4 figures main tex

    Π­Ρ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ примСнСния Π²ΠΈΡ‚Π°ΠΌΠΈΠ½Π½Ρ‹Ρ… комплСксов Π² Π²ΠΈΠ΄Π΅ ΠΌΠ°Ρ€ΠΌΠ΅Π»Π°Π΄Π½Ρ‹Ρ… пастилок Ρƒ Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹Ρ… Π΄Π΅Ρ‚Π΅ΠΉ ΠΈ Π΄Π΅Ρ‚Π΅ΠΉ с аллСргичСскими заболСваниями дошкольного ΠΈ школьного возраста

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    Background. Vitamins and minerals are significant components of the diet of a person of any age. Nowadays, when there is a focus on the β€˜Western’ type of food, it is impossible to get the necessary amount of all vitamins and minerals with a normal diet, which explains the high prevalence of hypovitaminosis in children. It is known that children with allergic diseases have a lower provision of vitamins as compared to apparently healthy children, which is the rationale for the relevance of this study.Our aim was to evaluate the efficacy and tolerability of vitamin complexes in children, including children with allergic reactions.Patients and Methods. The work was performed at the Federal State Autonomous Institution β€˜NMRC for Children’s Health’ of the Ministry of Healthcare of Russia from February to August 2017. We examined 90 apparently healthy children without severe somatic pathology at the age of 4–14 years, including 17 children with a history of allergic reactions. The children were divided into 2 groups. Group 1 received marmalade pastilles with vitamins C (16–27% of the recommended dietary allowance, RDA), E (29–40% of the RDA), A (24–34% of the RDA), B5 (40–80% of the RDA) , B9 (18–35% of the RDA), and D3 (4–9% of the RDA). Group 2 received marmalade pastilles with vitamins C (57–80% of the RDA), E (50–86% of the RDA), A (40–80% of the RDA), B5 (143–167% of the RDA), B3 (44 –73% of the RDA), D3 (10% of the RDA), B6 (82–117% of the RDA), and B12 (83–167% of the RDA). The tolerance of the vitamin complex was evaluated by the questionnaire method. The provision of vitamins C and B6 was evaluated in 39 children by an hourly urinary excretion of vitamins at the beginning of the study before taking the vitamin complex and 1 month after the start of intake.Results. The studied vitamin complexes showed good clinical tolerance in all children, including those with a history of allergic reactions to vitamin-mineral complexes. Evaluation of the efficacy of the vitamin complex in the 2nd group showed an improved provision, especially in children who had a deep deficiency of vitamins C (10%) and B6 (22%). At the same time, the excretion of vitamin B6 metabolite increased by 42.2%.Conclusion. The study showed the effective absorption of the studied vitamins and the good tolerability of the used vitamin complexes, including children with a history of allergic reactions to vitamin-mineral complexes.ОбоснованиС. Π’ΠΈΡ‚Π°ΠΌΠΈΠ½Ρ‹ ΠΈ ΠΌΠΈΠ½Π΅Ρ€Π°Π»ΡŒΠ½Ρ‹Π΅ вСщСства β€” Π·Π½Π°Ρ‡ΠΈΠΌΡ‹Π΅ ΡΠΎΡΡ‚Π°Π²Π»ΡΡŽΡ‰ΠΈΠ΅ Ρ€Π°Ρ†ΠΈΠΎΠ½Π° Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° любого возраста. Π’ соврСмСнном ΠΌΠΈΡ€Π΅, ΠΎΡ€ΠΈΠ΅Π½Ρ‚ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠΌ Π½Π° Β«Π·Π°ΠΏΠ°Π΄Π½Ρ‹ΠΉΒ» Ρ‚ΠΈΠΏ питания, Π½Π΅Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ ΠΏΠΎΠ»ΡƒΡ‡ΠΈΡ‚ΡŒ Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎΠ΅ количСство всСх Π²ΠΈΡ‚Π°ΠΌΠΈΠ½ΠΎΠ² ΠΈ ΠΌΠΈΠ½Π΅Ρ€Π°Π»ΡŒΠ½Ρ‹Ρ… вСщСств с ΠΎΠ±Ρ‹Ρ‡Π½Ρ‹ΠΌ Ρ€Π°Ρ†ΠΈΠΎΠ½ΠΎΠΌ, Ρ‡Ρ‚ΠΎ ΠΎΠ±ΡŠΡΡΠ½ΡΠ΅Ρ‚ Π²Ρ‹ΡΠΎΠΊΡƒΡŽ Ρ€Π°ΡΠΏΡ€ΠΎΡΡ‚Ρ€Π°Π½Π΅Π½Π½ΠΎΡΡ‚ΡŒ Π³ΠΈΠΏΠΎΠ²ΠΈΡ‚Π°ΠΌΠΈΠ½ΠΎΠ·ΠΎΠ² Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ. Π˜Π·Π²Π΅ΡΡ‚Π½ΠΎ, Ρ‡Ρ‚ΠΎ Π΄Π΅Ρ‚ΠΈ с аллСргичСскими заболСваниями ΠΈΠΌΠ΅ΡŽΡ‚ Π±ΠΎΠ»Π΅Π΅ Π½ΠΈΠ·ΠΊΡƒΡŽ ΠΎΠ±Π΅ΡΠΏΠ΅Ρ‡Π΅Π½Π½ΠΎΡΡ‚ΡŒ Π²ΠΈΡ‚Π°ΠΌΠΈΠ½Π°ΠΌΠΈ ΠΏΠΎ ΡΡ€Π°Π²Π½Π΅Π½ΠΈΡŽ с практичСски Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹ΠΌΠΈ Π΄Π΅Ρ‚ΡŒΠΌΠΈ, Ρ‡Π΅ΠΌ ΠΈ обоснована Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ Π΄Π°Π½Π½ΠΎΠ³ΠΎ исслСдования.ЦСль исслСдования β€” ΠΎΡ†Π΅Π½ΠΈΡ‚ΡŒ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΈ ΠΏΠ΅Ρ€Π΅Π½ΠΎΡΠΈΠΌΠΎΡΡ‚ΡŒ Π²ΠΈΡ‚Π°ΠΌΠΈΠ½Π½Ρ‹Ρ… комплСксов Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ, Π² Ρ‚ΠΎΠΌ числС Π΄Π΅Ρ‚Π΅ΠΉ с аллСргичСскими рСакциями.ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π Π°Π±ΠΎΡ‚Π° Π²Ρ‹ΠΏΠΎΠ»Π½Π΅Π½Π° Π² ЀГАУ «НМИЦ Π·Π΄ΠΎΡ€ΠΎΠ²ΡŒΡ Π΄Π΅Ρ‚Π΅ΠΉΒ» ΠœΠΈΠ½Π·Π΄Ρ€Π°Π²Π° России с фСвраля ΠΏΠΎ август 2017 Π³. ОбслСдовано 90 практичСски Π·Π΄ΠΎΡ€ΠΎΠ²Ρ‹Ρ… Π΄Π΅Ρ‚Π΅ΠΉ Π±Π΅Π· тяТСлой соматичСской ΠΏΠ°Ρ‚ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π² возрастС 4–14 Π»Π΅Ρ‚, Π² Ρ‚ΠΎΠΌ числС 17 Π΄Π΅Ρ‚Π΅ΠΉ с аллСргичСскими рСакциями Π² Π°Π½Π°ΠΌΠ½Π΅Π·Π΅. Π”Π΅Ρ‚ΠΈ Π±Ρ‹Π»ΠΈ Ρ€Π°Π·Π΄Π΅Π»Π΅Π½Ρ‹ Π½Π° 2 Π³Ρ€ΡƒΠΏΠΏΡ‹. Π“Ρ€ΡƒΠΏΠΏΠ° 1 ΠΏΠΎΠ»ΡƒΡ‡Π°Π»Π° ΠΌΠ°Ρ€ΠΌΠ΅Π»Π°Π΄Π½Ρ‹Π΅ пастилки с Π²ΠΈΡ‚Π°ΠΌΠΈΠ½Π°ΠΌΠΈ Π‘ (16–27% ΠΎΡ‚ Ρ€Π΅ΠΊΠΎΠΌΠ΅Π½Π΄ΡƒΠ΅ΠΌΠΎΠΉ Π½ΠΎΡ€ΠΌΡ‹ потрСблСния, РНП), Π• (29–40% ΠΎΡ‚ РНП), А (24–34% ΠΎΡ‚ РНП), B5 (40–80% ΠΎΡ‚ РНП), B9 (18–35% ΠΎΡ‚ РНП) ΠΈ D3 (4–9% ΠΎΡ‚ РНП). Π“Ρ€ΡƒΠΏΠΏΠ° 2 ΠΏΠΎΠ»ΡƒΡ‡Π°Π»Π° ΠΌΠ°Ρ€ΠΌΠ΅Π»Π°Π΄Π½Ρ‹Π΅ пастилки с Π²ΠΈΡ‚Π°ΠΌΠΈΠ½Π°ΠΌΠΈ Π‘ (57–80% ΠΎΡ‚ РНП), Π• (50–86% ΠΎΡ‚ РНП), А (40–80% ΠΎΡ‚ РНП), B5 (143–167% ΠΎΡ‚ РНП), B3 (44–73% ΠΎΡ‚ РНП), D3 (10% ΠΎΡ‚ РНП), Π’6 (82–117% ΠΎΡ‚ РНП) ΠΈ Π’12 (83–167% ΠΎΡ‚ РНП). ΠžΡ†Π΅Π½ΠΊΡƒ пСрСносимости Π²ΠΈΡ‚Π°ΠΌΠΈΠ½Π½ΠΎΠ³ΠΎ комплСкса осущСствляли опросно-Π°Π½ΠΊΠ΅Ρ‚Π½Ρ‹ΠΌ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ. ΠžΠ±Π΅ΡΠΏΠ΅Ρ‡Π΅Π½Π½ΠΎΡΡ‚ΡŒ Π²ΠΈΡ‚Π°ΠΌΠΈΠ½Π°ΠΌΠΈ Π‘ ΠΈ Π’6 ΠΎΡ†Π΅Π½ΠΈΠ²Π°Π»ΠΈ Ρƒ 39 Π΄Π΅Ρ‚Π΅ΠΉ ΠΏΠΎ часовой экскрСции Π²ΠΈΡ‚Π°ΠΌΠΈΠ½ΠΎΠ² с ΠΌΠΎΡ‡ΠΎΠΉ Π² Π½Π°Ρ‡Π°Π»Π΅ исслСдования ΠΏΠ΅Ρ€Π΅Π΄ Π½Π°Ρ‡Π°Π»ΠΎΠΌ ΠΏΡ€ΠΈΠ΅ΠΌΠ° Π²ΠΈΡ‚Π°ΠΌΠΈΠ½Π½ΠΎΠ³ΠΎ комплСкса ΠΈ Ρ‡Π΅Ρ€Π΅Π· 1 мСс.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. Π˜ΡΡΠ»Π΅Π΄ΡƒΠ΅ΠΌΡ‹Π΅ Π²ΠΈΡ‚Π°ΠΌΠΈΠ½Π½Ρ‹Π΅ комплСксы ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ Ρ…ΠΎΡ€ΠΎΡˆΡƒΡŽ ΠΊΠ»ΠΈΠ½ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ ΠΏΠ΅Ρ€Π΅Π½ΠΎΡΠΈΠΌΠΎΡΡ‚ΡŒ Ρƒ всСх Π΄Π΅Ρ‚Π΅ΠΉ, Π²ΠΊΠ»ΡŽΡ‡Π°Ρ Π»ΠΈΡ† с аллСргичСскими рСакциями Π½Π° Π²ΠΈΡ‚Π°ΠΌΠΈΠ½Π½ΠΎ-ΠΌΠΈΠ½Π΅Ρ€Π°Π»ΡŒΠ½Ρ‹Π΅ комплСксы Π² Π°Π½Π°ΠΌΠ½Π΅Π·Π΅. ΠžΡ†Π΅Π½ΠΊΠ° эффСктивности примСнСния Π²ΠΈΡ‚Π°ΠΌΠΈΠ½Π½ΠΎΠ³ΠΎ комплСкса Π²ΠΎ 2-ΠΉ Π³Ρ€ΡƒΠΏΠΏΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Π»Π° ΡƒΠ»ΡƒΡ‡ΡˆΠ΅Π½ΠΈΠ΅ обСспСчСнности, особСнно Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ, ΠΈΠΌΠ΅Π²ΡˆΠΈΡ… Π³Π»ΡƒΠ±ΠΎΠΊΠΈΠΉ Π΄Π΅Ρ„ΠΈΡ†ΠΈΡ‚ Π²ΠΈΡ‚Π°ΠΌΠΈΠ½ΠΎΠ² Π‘ (10%) ΠΈ Π’6 (22%). ΠŸΡ€ΠΈ этом экскрСция ΠΌΠ΅Ρ‚Π°Π±ΠΎΠ»ΠΈΡ‚Π° Π²ΠΈΡ‚Π°ΠΌΠΈΠ½Π° Π’6 ΠΏΠΎΠ²Ρ‹ΡΠΈΠ»Π°ΡΡŒ Π½Π° 42,2%.Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ΅ исслСдованиС ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ эффСктивноС усвоСниС исслСдованных Π²ΠΈΡ‚Π°ΠΌΠΈΠ½ΠΎΠ² ΠΈ Ρ…ΠΎΡ€ΠΎΡˆΡƒΡŽ ΠΏΠ΅Ρ€Π΅Π½ΠΎΡΠΈΠΌΠΎΡΡ‚ΡŒ ΠΏΡ€ΠΈΠΌΠ΅Π½ΡΠ²ΡˆΠΈΡ…ΡΡ Π²ΠΈΡ‚Π°ΠΌΠΈΠ½Π½Ρ‹Ρ… комплСксов, Π² Ρ‚ΠΎΠΌ числС Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ с аллСргичСскими рСакциями Π½Π° Π²ΠΈΡ‚Π°ΠΌΠΈΠ½Π½ΠΎ-ΠΌΠΈΠ½Π΅Ρ€Π°Π»ΡŒΠ½Ρ‹Π΅ комплСксы Π² Π°Π½Π°ΠΌΠ½Π΅Π·Π΅

    ΠšΠΈΡˆΠ΅Ρ‡Π½Π°Ρ ΠΌΠΈΠΊΡ€ΠΎΠ±ΠΈΠΎΡ‚Π° ΠΈ аллСргия. ΠŸΡ€ΠΎ- ΠΈ ΠΏΡ€Π΅Π±ΠΈΠΎΡ‚ΠΈΠΊΠΈ Π² ΠΏΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΠ΅ ΠΈ Π»Π΅Ρ‡Π΅Π½ΠΈΠΈ аллСргичСских Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ

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    Intestinal microbiota is the factor that identifies considerably the human health. The impact of the microbial factor on a child begins long before his birth. Children have certain features in forming of immune response and intestinal microbiocenosis even before birth. Decline in diversity of intestinal microbiota is common in children with allergic disease even during first months of life, before allergic pathology development. Capabilities for microbiota development adjustment are sufficiently restricted. However it is clinically proven that early (within the first hours of life) breastfeeding attachment, breastfeeding itself within at least first 6 months of life, the use of prebiotics in milk formulas as well as the use of probiotics can give positive results on allergy management. In this review we present results of recent metaanalyses and consensus papers of international medical communities about use of probiotics and prebiotics in prevention and treatment of allergic diseases. Despite great scientific and practical interest to this topic, authors of metaanalyses bring our attention to the lack of evidence-based clinical trials.ΠœΠΈΠΊΡ€ΠΎΠ±ΠΈΠΎΡ‚Π° ΠΊΠΈΡˆΠ΅Ρ‡Π½ΠΈΠΊΠ° являСтся Ρ„Π°ΠΊΡ‚ΠΎΡ€ΠΎΠΌ, Π² Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ стСпСни ΠΎΠΏΡ€Π΅Π΄Π΅Π»ΡΡŽΡ‰ΠΈΠΌ Π·Π΄ΠΎΡ€ΠΎΠ²ΡŒΠ΅ Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ°. ВоздСйствиС Π½Π° Ρ€Π΅Π±Π΅Π½ΠΊΠ° ΠΌΠΈΠΊΡ€ΠΎΠ±Π½ΠΎΠ³ΠΎ Ρ„Π°ΠΊΡ‚ΠΎΡ€Π° начинаСтся Π·Π°Π΄ΠΎΠ»Π³ΠΎ Π΄ΠΎ роТдСния, ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Π½Ρ‹Π΅ особСнности формирования ΠΈΠΌΠΌΡƒΠ½Π½ΠΎΠ³ΠΎ ΠΎΡ‚Π²Π΅Ρ‚Π° ΠΈ ΠΌΠΈΠΊΡ€ΠΎΠ±ΠΈΠΎΡ†Π΅Π½ΠΎΠ·Π° ΠΊΠΈΡˆΠ΅Ρ‡Π½ΠΈΠΊΠ° Π΄Π΅Ρ‚ΠΈ ΠΈΠΌΠ΅ΡŽΡ‚ Π΅Ρ‰Π΅ Π΄ΠΎ роТдСния. Для Π΄Π΅Ρ‚Π΅ΠΉ с аллСргичСскими заболСваниями Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€Π½ΠΎ сниТСниС разнообразия ΠΊΠΈΡˆΠ΅Ρ‡Π½ΠΎΠΉ ΠΌΠΈΠΊΡ€ΠΎΠ±ΠΈΠΎΡ‚Ρ‹ Π² ΠΏΠ΅Ρ€Π²Ρ‹Π΅ мСсяцы ΠΆΠΈΠ·Π½ΠΈ β€” Π΅Ρ‰Π΅ Π΄ΠΎ развития аллСргичСской ΠΏΠ°Ρ‚ΠΎΠ»ΠΎΠ³ΠΈΠΈ. ВозмоТности ΠΊΠΎΡ€Ρ€Π΅ΠΊΡ‚ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ процСсс формирования ΠΌΠΈΠΊΡ€ΠΎΠ±ΠΈΠΎΡ‚Ρ‹ достаточно ΠΎΠ³Ρ€Π°Π½ΠΈΡ‡Π΅Π½Ρ‹, ΠΎΠ΄Π½Π°ΠΊΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ Ρ€Π°Π½Π½Π΅Π΅ (Π² Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ ΠΏΠ΅Ρ€Π²Ρ‹Ρ… часов ΠΆΠΈΠ·Π½ΠΈ) ΠΏΡ€ΠΈΠΊΠ»Π°Π΄Ρ‹Π²Π°Π½ΠΈΠ΅ ΠΊ Π³Ρ€ΡƒΠ΄ΠΈ, Π³Ρ€ΡƒΠ΄Π½ΠΎΠ΅ вскармливаниС Π² Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ ΠΊΠ°ΠΊ ΠΌΠΈΠ½ΠΈΠΌΡƒΠΌ ΠΏΠ΅Ρ€Π²Ρ‹Ρ… 6 мСс ΠΆΠΈΠ·Π½ΠΈ, использованиС ΠΏΡ€Π΅Π±ΠΈΠΎΡ‚ΠΈΠΊΠΎΠ² Π² составС дСтских ΠΌΠΎΠ»ΠΎΡ‡Π½Ρ‹Ρ… смСсСй, Π° Ρ‚Π°ΠΊΠΆΠ΅ ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΡ€ΠΎΠ±ΠΈΠΎΡ‚ΠΈΠΊΠΎΠ² с Π΄ΠΎΠΊΠ°Π·Π°Π½Π½ΠΎΠΉ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒΡŽ ΠΌΠΎΠΆΠ΅Ρ‚ Π΄Π°Π²Π°Ρ‚ΡŒ ΠΏΠΎΠ»ΠΎΠΆΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Π΅ эффСкты Π² ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΈ ΠΏΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΠΈ Π°Π»Π»Π΅Ρ€Π³ΠΈΠΈ. Π’ ΠΎΠ±Π·ΠΎΡ€Π΅ ΠΏΡ€ΠΈΠ²Π΅Π΄Π΅Π½Ρ‹ основныС Π²Ρ‹Π²ΠΎΠ΄Ρ‹ послСдних ΠΌΠ΅Ρ‚Π°Π°Π½Π°Π»ΠΈΠ·ΠΎΠ² ΠΈ ΡΠΎΠ³Π»Π°ΡΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… Π΄ΠΎΠΊΡƒΠΌΠ΅Π½Ρ‚ΠΎΠ² ΠΌΠ΅ΠΆΠ΄ΡƒΠ½Π°Ρ€ΠΎΠ΄Π½Ρ‹Ρ… мСдицинских сообщСств Π² ΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠΈ возмоТности использования ΠΏΡ€ΠΎ- ΠΈ ΠΏΡ€Π΅Π±ΠΈΠΎΡ‚ΠΈΠΊΠΎΠ² Π² ΠΏΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΠ΅ ΠΈ Π»Π΅Ρ‡Π΅Π½ΠΈΠΈ аллСргичСских Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. НСсмотря Π½Π° большой Π½Π°ΡƒΡ‡Π½Ρ‹ΠΉ ΠΈ практичСский интСрСс ΠΊ ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΠ΅, Π°Π²Ρ‚ΠΎΡ€Ρ‹ ΠΌΠ΅Ρ‚Π°Π°Π½Π°Π»ΠΈΠ·ΠΎΠ² ΡƒΠΊΠ°Π·Ρ‹Π²Π°ΡŽΡ‚ Π½Π° нСдостаточноС количСство клиничСских исслСдований, ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π½Ρ‹Ρ… с соблюдСниСм ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏΠΎΠ² Π΄ΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Ρ‹

    Evaluation of the Efficacy and Tolerability of Vitamin Complexes in Marmalade Pastilles in Healthy Children and Children With Allergic Diseases of Pre-School and School Age

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    Background. Vitamins and minerals are significant components of the diet of a person of any age. Nowadays, when there is a focus on the β€˜Western’ type of food, it is impossible to get the necessary amount of all vitamins and minerals with a normal diet, which explains the high prevalence of hypovitaminosis in children. It is known that children with allergic diseases have a lower provision of vitamins as compared to apparently healthy children, which is the rationale for the relevance of this study.Our aim was to evaluate the efficacy and tolerability of vitamin complexes in children, including children with allergic reactions.Patients and Methods. The work was performed at the Federal State Autonomous Institution β€˜NMRC for Children’s Health’ of the Ministry of Healthcare of Russia from February to August 2017. We examined 90 apparently healthy children without severe somatic pathology at the age of 4–14 years, including 17 children with a history of allergic reactions. The children were divided into 2 groups. Group 1 received marmalade pastilles with vitamins C (16–27% of the recommended dietary allowance, RDA), E (29–40% of the RDA), A (24–34% of the RDA), B5 (40–80% of the RDA) , B9 (18–35% of the RDA), and D3 (4–9% of the RDA). Group 2 received marmalade pastilles with vitamins C (57–80% of the RDA), E (50–86% of the RDA), A (40–80% of the RDA), B5 (143–167% of the RDA), B3 (44 –73% of the RDA), D3 (10% of the RDA), B6 (82–117% of the RDA), and B12 (83–167% of the RDA). The tolerance of the vitamin complex was evaluated by the questionnaire method. The provision of vitamins C and B6 was evaluated in 39 children by an hourly urinary excretion of vitamins at the beginning of the study before taking the vitamin complex and 1 month after the start of intake.Results. The studied vitamin complexes showed good clinical tolerance in all children, including those with a history of allergic reactions to vitamin-mineral complexes. Evaluation of the efficacy of the vitamin complex in the 2nd group showed an improved provision, especially in children who had a deep deficiency of vitamins C (10%) and B6 (22%). At the same time, the excretion of vitamin B6 metabolite increased by 42.2%.Conclusion. The study showed the effective absorption of the studied vitamins and the good tolerability of the used vitamin complexes, including children with a history of allergic reactions to vitamin-mineral complexes
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