24 research outputs found
ΠΡΠ³Π°Π½ΡΠ·Π°ΡΡΡ Π±ΡΡ Π³Π°Π»ΡΠ΅ΡΡΡΠΊΠΎΠ³ΠΎ ΠΎΠ±Π»ΡΠΊΡ Ρ ΡΡΠ±'ΡΠΊΡΡΠ² ΠΌΠ°Π»ΠΎΠ³ΠΎ ΠΏΡΠ΄ΠΏΡΠΈΡΠΌΠ½ΠΈΡΡΠ²Π°
Along with continuing changes in the tax law, the requirements to the organization of small business accounting are changing, too. The article provides the analysis of normative legal documents governing small business accounting. The accounting requirements for small businesses of general and simplified tax accounts have been systematized. The necessity and essentiality of drawing primary documents has been grounded. The list and order of making tax registers and preparation of financial statements according to the chosen form of accounting organization have been considered
ΠΡΠ³Π°Π½ΡΠ·Π°ΡΡΡ Π±ΡΡ Π³Π°Π»ΡΠ΅ΡΡΡΠΊΠΎΠ³ΠΎ ΠΎΠ±Π»ΡΠΊΡ Ρ ΡΡΠ±'ΡΠΊΡΡΠ² ΠΌΠ°Π»ΠΎΠ³ΠΎ ΠΏΡΠ΄ΠΏΡΠΈΡΠΌΠ½ΠΈΡΡΠ²Π°
Along with continuing changes in the tax law, the requirements to the organization of small business accounting are changing, too. The article provides the analysis of normative legal documents governing small business accounting. The accounting requirements for small businesses of general and simplified tax accounts have been systematized. The necessity and essentiality of drawing primary documents has been grounded. The list and order of making tax registers and preparation of financial statements according to the chosen form of accounting organization have been considered
Visualization as a method of overcoming anxiety and nervous tension, reducing symptoms of depression and stress in difficult life situation
The problem of overcoming anxiety and nervous tension has turned out to be one of the most pressing in the modern world, which has found itself in an unprecedented situation of uncertainty and instability. Like many other significant negative processes on a global scale, it provoked an increase in peopleβs anxiety levels. A personβs uncertainty about tomorrow, without the opportunity to live a normal way of life, has created the preconditions for the occurrence of excessive emotional reactions to ongoing events, a decrease in performance and the perception of the surrounding world or many objects within it as potentially dangerous or stressful. The study showed that adaptive coping strategies are interconnected with the processes of self-knowledge, revaluation of values and positive self-attitude, visualization bei8ng one of them.These coping strategies include the use of visualization techniques in situations that are accompanied by anxiety, nervous tension, stress and depression. The relevance of this study lies in the fact that in the era of instability and uncertainty, people experience stress much more often. This technique can not only help cheer up, but also help improve well-being. Anxiety causes fear; sudden mood swings; tearfulness; irritability; persistently low mood, gloomy forebodings
Arquivar atividades em termos de autenticidade de documentos eletrônicos e variação do número de cópias
The article is devoted to the problems of archive activity during the digital era, which are conditioned from the authors' point of view by the introduction of electronic documents that have changed the content of paperwork and archiving key categories - authenticity and copy number variation, as well as related originality and authenticity. The technologies of work in the archive, always considered as a unique system of originals are based on the traditional understanding of these categories. Using the method of expert assessments during the determination of key category content, the authors conclude that the current activity of the archives is aimed at copy production activity increase, their management and the provision of authenticity, reliability, integrity and suitability for use. Nowadays the issue of document archiving requires the consolidation of state and non-state structure efforts to develop a new attitude to the authenticity of electronic documents, to change the usual nature of archival institution interaction with users and interested citizens, state authorities and administration, law enforcement and judicial system.El artΓculo estΓ‘ dedicado a los problemas de la actividad de archivo durante la era digital, que estΓ‘n condicionados desde el punto de vista de los autores por la introducciΓ³n de documentos electrΓ³nicos que han cambiado el contenido del papeleo y las categorΓas clave de archivo: autenticidad y variaciΓ³n del nΓΊmero de copias, como asΓ como la originalidad y autenticidad relacionadas. Las tecnologΓas de trabajo en el archivo, siempre consideradas como un sistema ΓΊnico de originales, se basan en el entendimiento tradicional de estas categorΓas. Usando el mΓ©todo de evaluaciones de expertos durante la determinaciΓ³n del contenido de la categorΓa clave, los autores concluyen que la actividad actual de los archivos estΓ‘ dirigida a aumentar la actividad de producciΓ³n de copias, su gestiΓ³n y la provisiΓ³n de autenticidad, confiabilidad, integridad y adecuaciΓ³n para su uso. Hoy en dΓa, el tema del archivo de documentos requiere la consolidaciΓ³n de los esfuerzos de la estructura estatal y no estatal para desarrollar una nueva actitud hacia la autenticidad de los documentos electrΓ³nicos, para cambiar la naturaleza habitual de la interacciΓ³n de la instituciΓ³n archivΓstica con los usuarios y ciudadanos interesados, las autoridades estatales, la administraciΓ³n y la ley.O artigo Γ© dedicado aos problemas da atividade de arquivo durante a era digital, eles sΓ£o condicionados a partir do ponto de vista dos autores para a introdução de documentos eletrΓ΄nicos que mudaram o conteΓΊdo de documentos e categorias de arquivos-chave: autenticidade e variação do nΓΊmero de cΓ³pias, bem como a originalidade e autenticidade relacionadas. Tecnologias de trabalho no arquivo, sempre considerado como um ΓΊnico sistema original, com base no entendimento tradicional destas categorias. Usando o mΓ©todo de avaliaçáes de peritos para a determinação da categoria-chave, os autores concluem que a atividade de arquivos atual visa aumentar cΓ³pias atividade de produção, gestΓ£o e prestação de autenticidade, confiabilidade, integridade e adequação para uso. Hoje, a questΓ£o do arquivamento de documentos requer a consolidação dos esforΓ§os de estruturas estatais e nΓ£o-estatais para desenvolver uma nova atitude em relação Γ autenticidade dos documentos eletrΓ΄nicos, para mudar a natureza habitual da interação da instituição de arquivo utilizadores e cidadΓ£os interessados, autoridades estatais, administração e direito
Controlling local thermalization dynamics in a Floquet-engineered dipolar ensemble
Understanding the microscopic mechanisms of thermalization in closed quantum
systems is among the key challenges in modern quantum many-body physics. We
demonstrate a method to probe local thermalization in a large-scale many-body
system by exploiting its inherent disorder, and use this to uncover the
thermalization mechanisms in a three-dimensional, dipolar-interacting spin
system with tunable interactions. Utilizing advanced Hamiltonian engineering
techniques to explore a range of spin Hamiltonians, we observe a striking
change in the characteristic shape and timescale of local correlation decay as
we vary the engineered exchange anisotropy. We show that these observations
originate from the system's intrinsic many-body dynamics and reveal the
signatures of conservation laws within localized clusters of spins, which do
not readily manifest using global probes. Our method provides an exquisite lens
into the tunable nature of local thermalization dynamics, and enables detailed
studies of scrambling, thermalization and hydrodynamics in strongly-interacting
quantum systems.Comment: 6 pages, 4 figures main tex
ΠΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π½ΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² Π² Π²ΠΈΠ΄Π΅ ΠΌΠ°ΡΠΌΠ΅Π»Π°Π΄Π½ΡΡ ΠΏΠ°ΡΡΠΈΠ»ΠΎΠΊ Ρ Π·Π΄ΠΎΡΠΎΠ²ΡΡ Π΄Π΅ΡΠ΅ΠΉ ΠΈ Π΄Π΅ΡΠ΅ΠΉ Ρ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ Π΄ΠΎΡΠΊΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΡΠΊΠΎΠ»ΡΠ½ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°
Background. Vitamins and minerals are significant components of the diet of a person of any age. Nowadays, when there is a focus on the βWesternβ type of food, it is impossible to get the necessary amount of all vitamins and minerals with a normal diet, which explains the high prevalence of hypovitaminosis in children. It is known that children with allergic diseases have a lower provision of vitamins as compared to apparently healthy children, which is the rationale for the relevance of this study.Our aim was to evaluate the efficacy and tolerability of vitamin complexes in children, including children with allergic reactions.Patients and Methods. The work was performed at the Federal State Autonomous Institution βNMRC for Childrenβs Healthβ of the Ministry of Healthcare of Russia from February to August 2017. We examined 90 apparently healthy children without severe somatic pathology at the age of 4β14 years, including 17 children with a history of allergic reactions. The children were divided into 2 groups. Group 1 received marmalade pastilles with vitamins C (16β27% of the recommended dietary allowance, RDA), E (29β40% of the RDA), A (24β34% of the RDA), B5 (40β80% of the RDA) , B9 (18β35% of the RDA), and D3 (4β9% of the RDA). Group 2 received marmalade pastilles with vitamins C (57β80% of the RDA), E (50β86% of the RDA), A (40β80% of the RDA), B5 (143β167% of the RDA), B3 (44 β73% of the RDA), D3 (10% of the RDA), B6 (82β117% of the RDA), and B12 (83β167% of the RDA). The tolerance of the vitamin complex was evaluated by the questionnaire method. The provision of vitamins C and B6 was evaluated in 39 children by an hourly urinary excretion of vitamins at the beginning of the study before taking the vitamin complex and 1 month after the start of intake.Results. The studied vitamin complexes showed good clinical tolerance in all children, including those with a history of allergic reactions to vitamin-mineral complexes. Evaluation of the efficacy of the vitamin complex in the 2nd group showed an improved provision, especially in children who had a deep deficiency of vitamins C (10%) and B6 (22%). At the same time, the excretion of vitamin B6 metabolite increased by 42.2%.Conclusion. The study showed the effective absorption of the studied vitamins and the good tolerability of the used vitamin complexes, including children with a history of allergic reactions to vitamin-mineral complexes.ΠΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠ΅. ΠΠΈΡΠ°ΠΌΠΈΠ½Ρ ΠΈ ΠΌΠΈΠ½Π΅ΡΠ°Π»ΡΠ½ΡΠ΅ Π²Π΅ΡΠ΅ΡΡΠ²Π° β Π·Π½Π°ΡΠΈΠΌΡΠ΅ ΡΠΎΡΡΠ°Π²Π»ΡΡΡΠΈΠ΅ ΡΠ°ΡΠΈΠΎΠ½Π° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π»ΡΠ±ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°. Π ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΌ ΠΌΠΈΡΠ΅, ΠΎΡΠΈΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΌ Π½Π° Β«Π·Π°ΠΏΠ°Π΄Π½ΡΠΉΒ» ΡΠΈΠΏ ΠΏΠΈΡΠ°Π½ΠΈΡ, Π½Π΅Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ ΠΏΠΎΠ»ΡΡΠΈΡΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΠ΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ Π²ΡΠ΅Ρ
Π²ΠΈΡΠ°ΠΌΠΈΠ½ΠΎΠ² ΠΈ ΠΌΠΈΠ½Π΅ΡΠ°Π»ΡΠ½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ² Ρ ΠΎΠ±ΡΡΠ½ΡΠΌ ΡΠ°ΡΠΈΠΎΠ½ΠΎΠΌ, ΡΡΠΎ ΠΎΠ±ΡΡΡΠ½ΡΠ΅Ρ Π²ΡΡΠΎΠΊΡΡ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΡ Π³ΠΈΠΏΠΎΠ²ΠΈΡΠ°ΠΌΠΈΠ½ΠΎΠ·ΠΎΠ² Ρ Π΄Π΅ΡΠ΅ΠΉ. ΠΠ·Π²Π΅ΡΡΠ½ΠΎ, ΡΡΠΎ Π΄Π΅ΡΠΈ Ρ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ ΠΈΠΌΠ΅ΡΡ Π±ΠΎΠ»Π΅Π΅ Π½ΠΈΠ·ΠΊΡΡ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½Π½ΠΎΡΡΡ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π°ΠΌΠΈ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΠΌΠΈ Π΄Π΅ΡΡΠΌΠΈ, ΡΠ΅ΠΌ ΠΈ ΠΎΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½Π° Π°ΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΎΡΠ΅Π½ΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠΈΠΌΠΎΡΡΡ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π½ΡΡ
ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ² Ρ Π΄Π΅ΡΠ΅ΠΉ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Π΄Π΅ΡΠ΅ΠΉ Ρ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ΅Π°ΠΊΡΠΈΡΠΌΠΈ.ΠΠ΅ΡΠΎΠ΄Ρ. Π Π°Π±ΠΎΡΠ° Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π° Π² Π€ΠΠΠ£ Β«ΠΠΠΠ¦ Π·Π΄ΠΎΡΠΎΠ²ΡΡ Π΄Π΅ΡΠ΅ΠΉΒ» ΠΠΈΠ½Π·Π΄ΡΠ°Π²Π° Π ΠΎΡΡΠΈΠΈ Ρ ΡΠ΅Π²ΡΠ°Π»Ρ ΠΏΠΎ Π°Π²Π³ΡΡΡ 2017 Π³. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ 90 ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄Π΅ΡΠ΅ΠΉ Π±Π΅Π· ΡΡΠΆΠ΅Π»ΠΎΠΉ ΡΠΎΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ 4β14 Π»Π΅Ρ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ 17 Π΄Π΅ΡΠ΅ΠΉ Ρ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ΅Π°ΠΊΡΠΈΡΠΌΠΈ Π² Π°Π½Π°ΠΌΠ½Π΅Π·Π΅. ΠΠ΅ΡΠΈ Π±ΡΠ»ΠΈ ΡΠ°Π·Π΄Π΅Π»Π΅Π½Ρ Π½Π° 2 Π³ΡΡΠΏΠΏΡ. ΠΡΡΠΏΠΏΠ° 1 ΠΏΠΎΠ»ΡΡΠ°Π»Π° ΠΌΠ°ΡΠΌΠ΅Π»Π°Π΄Π½ΡΠ΅ ΠΏΠ°ΡΡΠΈΠ»ΠΊΠΈ Ρ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π°ΠΌΠΈ Π‘ (16β27% ΠΎΡ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄ΡΠ΅ΠΌΠΎΠΉ Π½ΠΎΡΠΌΡ ΠΏΠΎΡΡΠ΅Π±Π»Π΅Π½ΠΈΡ, Π ΠΠ), Π (29β40% ΠΎΡ Π ΠΠ), Π (24β34% ΠΎΡ Π ΠΠ), B5 (40β80% ΠΎΡ Π ΠΠ), B9 (18β35% ΠΎΡ Π ΠΠ) ΠΈ D3 (4β9% ΠΎΡ Π ΠΠ). ΠΡΡΠΏΠΏΠ° 2 ΠΏΠΎΠ»ΡΡΠ°Π»Π° ΠΌΠ°ΡΠΌΠ΅Π»Π°Π΄Π½ΡΠ΅ ΠΏΠ°ΡΡΠΈΠ»ΠΊΠΈ Ρ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π°ΠΌΠΈ Π‘ (57β80% ΠΎΡ Π ΠΠ), Π (50β86% ΠΎΡ Π ΠΠ), Π (40β80% ΠΎΡ Π ΠΠ), B5 (143β167% ΠΎΡ Π ΠΠ), B3 (44β73% ΠΎΡ Π ΠΠ), D3 (10% ΠΎΡ Π ΠΠ), Π6 (82β117% ΠΎΡ Π ΠΠ) ΠΈ Π12 (83β167% ΠΎΡ Π ΠΠ). ΠΡΠ΅Π½ΠΊΡ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠΈΠΌΠΎΡΡΠΈ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ»ΠΈ ΠΎΠΏΡΠΎΡΠ½ΠΎ-Π°Π½ΠΊΠ΅ΡΠ½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ. ΠΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½Π½ΠΎΡΡΡ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π°ΠΌΠΈ Π‘ ΠΈ Π6 ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ Ρ 39 Π΄Π΅ΡΠ΅ΠΉ ΠΏΠΎ ΡΠ°ΡΠΎΠ²ΠΎΠΉ ΡΠΊΡΠΊΡΠ΅ΡΠΈΠΈ Π²ΠΈΡΠ°ΠΌΠΈΠ½ΠΎΠ² Ρ ΠΌΠΎΡΠΎΠΉ Π² Π½Π°ΡΠ°Π»Π΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠ΅ΡΠ΅Π΄ Π½Π°ΡΠ°Π»ΠΎΠΌ ΠΏΡΠΈΠ΅ΠΌΠ° Π²ΠΈΡΠ°ΠΌΠΈΠ½Π½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΈ ΡΠ΅ΡΠ΅Π· 1 ΠΌΠ΅Ρ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΠ΅ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π½ΡΠ΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ Ρ
ΠΎΡΠΎΡΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΡΡ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠΈΠΌΠΎΡΡΡ Ρ Π²ΡΠ΅Ρ
Π΄Π΅ΡΠ΅ΠΉ, Π²ΠΊΠ»ΡΡΠ°Ρ Π»ΠΈΡ Ρ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ΅Π°ΠΊΡΠΈΡΠΌΠΈ Π½Π° Π²ΠΈΡΠ°ΠΌΠΈΠ½Π½ΠΎ-ΠΌΠΈΠ½Π΅ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ Π² Π°Π½Π°ΠΌΠ½Π΅Π·Π΅. ΠΡΠ΅Π½ΠΊΠ° ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° Π²ΠΎ 2-ΠΉ Π³ΡΡΠΏΠΏΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Π»Π° ΡΠ»ΡΡΡΠ΅Π½ΠΈΠ΅ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½Π½ΠΎΡΡΠΈ, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ Ρ Π΄Π΅ΡΠ΅ΠΉ, ΠΈΠΌΠ΅Π²ΡΠΈΡ
Π³Π»ΡΠ±ΠΎΠΊΠΈΠΉ Π΄Π΅ΡΠΈΡΠΈΡ Π²ΠΈΡΠ°ΠΌΠΈΠ½ΠΎΠ² Π‘ (10%) ΠΈ Π6 (22%). ΠΡΠΈ ΡΡΠΎΠΌ ΡΠΊΡΠΊΡΠ΅ΡΠΈΡ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ° Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° Π6 ΠΏΠΎΠ²ΡΡΠΈΠ»Π°ΡΡ Π½Π° 42,2%.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΡΡΠ²ΠΎΠ΅Π½ΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΡΡ
Π²ΠΈΡΠ°ΠΌΠΈΠ½ΠΎΠ² ΠΈ Ρ
ΠΎΡΠΎΡΡΡ ΠΏΠ΅ΡΠ΅Π½ΠΎΡΠΈΠΌΠΎΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ²ΡΠΈΡ
ΡΡ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π½ΡΡ
ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠΎΠ², Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ΅Π°ΠΊΡΠΈΡΠΌΠΈ Π½Π° Π²ΠΈΡΠ°ΠΌΠΈΠ½Π½ΠΎ-ΠΌΠΈΠ½Π΅ΡΠ°Π»ΡΠ½ΡΠ΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΡ Π² Π°Π½Π°ΠΌΠ½Π΅Π·Π΅
ΠΠΈΡΠ΅ΡΠ½Π°Ρ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΠ° ΠΈ Π°Π»Π»Π΅ΡΠ³ΠΈΡ. ΠΡΠΎ- ΠΈ ΠΏΡΠ΅Π±ΠΈΠΎΡΠΈΠΊΠΈ Π² ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠ΅ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ
Intestinal microbiota is the factor that identifies considerably the human health. The impact of the microbial factor on a child begins long before his birth. Children have certain features in forming of immune response and intestinal microbiocenosis even before birth. Decline in diversity of intestinal microbiota is common in children with allergic disease even during first months of life, before allergic pathology development. Capabilities for microbiota development adjustment are sufficiently restricted. However it is clinically proven that early (within the first hours of life) breastfeeding attachment, breastfeeding itself within at least first 6 months of life, the use of prebiotics in milk formulas as well as the use of probiotics can give positive results on allergy management. In this review we present results of recent metaanalyses and consensus papers of international medical communities about use of probiotics and prebiotics in prevention and treatment of allergic diseases. Despite great scientific and practical interest to this topic, authors of metaanalyses bring our attention to the lack of evidence-based clinical trials.ΠΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΠ° ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°ΠΊΡΠΎΡΠΎΠΌ, Π² Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡΠΈΠΌ Π·Π΄ΠΎΡΠΎΠ²ΡΠ΅ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. ΠΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π½Π° ΡΠ΅Π±Π΅Π½ΠΊΠ° ΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠ³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ° Π½Π°ΡΠΈΠ½Π°Π΅ΡΡΡ Π·Π°Π΄ΠΎΠ»Π³ΠΎ Π΄ΠΎ ΡΠΎΠΆΠ΄Π΅Π½ΠΈΡ, ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° ΠΈ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΠ΅Π½ΠΎΠ·Π° ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° Π΄Π΅ΡΠΈ ΠΈΠΌΠ΅ΡΡ Π΅ΡΠ΅ Π΄ΠΎ ΡΠΎΠΆΠ΄Π΅Π½ΠΈΡ. ΠΠ»Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΡΠ°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·ΠΈΡ ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ Π² ΠΏΠ΅ΡΠ²ΡΠ΅ ΠΌΠ΅ΡΡΡΡ ΠΆΠΈΠ·Π½ΠΈ β Π΅ΡΠ΅ Π΄ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ. ΠΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΡΠΎΠ²Π°ΡΡ ΠΏΡΠΎΡΠ΅ΡΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½Ρ, ΠΎΠ΄Π½Π°ΠΊΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΠ°Π½Π½Π΅Π΅ (Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΏΠ΅ΡΠ²ΡΡ
ΡΠ°ΡΠΎΠ² ΠΆΠΈΠ·Π½ΠΈ) ΠΏΡΠΈΠΊΠ»Π°Π΄ΡΠ²Π°Π½ΠΈΠ΅ ΠΊ Π³ΡΡΠ΄ΠΈ, Π³ΡΡΠ΄Π½ΠΎΠ΅ Π²ΡΠΊΠ°ΡΠΌΠ»ΠΈΠ²Π°Π½ΠΈΠ΅ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΊΠ°ΠΊ ΠΌΠΈΠ½ΠΈΠΌΡΠΌ ΠΏΠ΅ΡΠ²ΡΡ
6 ΠΌΠ΅Ρ ΠΆΠΈΠ·Π½ΠΈ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠ΅Π±ΠΈΠΎΡΠΈΠΊΠΎΠ² Π² ΡΠΎΡΡΠ°Π²Π΅ Π΄Π΅ΡΡΠΊΠΈΡ
ΠΌΠΎΠ»ΠΎΡΠ½ΡΡ
ΡΠΌΠ΅ΡΠ΅ΠΉ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΡΠΎΠ±ΠΈΠΎΡΠΈΠΊΠΎΠ² Ρ Π΄ΠΎΠΊΠ°Π·Π°Π½Π½ΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΌΠΎΠΆΠ΅Ρ Π΄Π°Π²Π°ΡΡ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΡΡΡΠ΅ΠΊΡΡ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ Π°Π»Π»Π΅ΡΠ³ΠΈΠΈ. Π ΠΎΠ±Π·ΠΎΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ Π²ΡΠ²ΠΎΠ΄Ρ ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΡ
ΠΌΠ΅ΡΠ°Π°Π½Π°Π»ΠΈΠ·ΠΎΠ² ΠΈ ΡΠΎΠ³Π»Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΡ
Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΠΎΠ² ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΡΡ
ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΡ
ΡΠΎΠΎΠ±ΡΠ΅ΡΡΠ² Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎ- ΠΈ ΠΏΡΠ΅Π±ΠΈΠΎΡΠΈΠΊΠΎΠ² Π² ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠ΅ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. ΠΠ΅ΡΠΌΠΎΡΡΡ Π½Π° Π±ΠΎΠ»ΡΡΠΎΠΉ Π½Π°ΡΡΠ½ΡΠΉ ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ ΠΊ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅, Π°Π²ΡΠΎΡΡ ΠΌΠ΅ΡΠ°Π°Π½Π°Π»ΠΈΠ·ΠΎΠ² ΡΠΊΠ°Π·ΡΠ²Π°ΡΡ Π½Π° Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΠ΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ
Ρ ΡΠΎΠ±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠΈΠ½ΡΠΈΠΏΠΎΠ² Π΄ΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ
Evaluation of the Efficacy and Tolerability of Vitamin Complexes in Marmalade Pastilles in Healthy Children and Children With Allergic Diseases of Pre-School and School Age
Background. Vitamins and minerals are significant components of the diet of a person of any age. Nowadays, when there is a focus on the βWesternβ type of food, it is impossible to get the necessary amount of all vitamins and minerals with a normal diet, which explains the high prevalence of hypovitaminosis in children. It is known that children with allergic diseases have a lower provision of vitamins as compared to apparently healthy children, which is the rationale for the relevance of this study.Our aim was to evaluate the efficacy and tolerability of vitamin complexes in children, including children with allergic reactions.Patients and Methods. The work was performed at the Federal State Autonomous Institution βNMRC for Childrenβs Healthβ of the Ministry of Healthcare of Russia from February to August 2017. We examined 90 apparently healthy children without severe somatic pathology at the age of 4β14 years, including 17 children with a history of allergic reactions. The children were divided into 2 groups. Group 1 received marmalade pastilles with vitamins C (16β27% of the recommended dietary allowance, RDA), E (29β40% of the RDA), A (24β34% of the RDA), B5 (40β80% of the RDA) , B9 (18β35% of the RDA), and D3 (4β9% of the RDA). Group 2 received marmalade pastilles with vitamins C (57β80% of the RDA), E (50β86% of the RDA), A (40β80% of the RDA), B5 (143β167% of the RDA), B3 (44 β73% of the RDA), D3 (10% of the RDA), B6 (82β117% of the RDA), and B12 (83β167% of the RDA). The tolerance of the vitamin complex was evaluated by the questionnaire method. The provision of vitamins C and B6 was evaluated in 39 children by an hourly urinary excretion of vitamins at the beginning of the study before taking the vitamin complex and 1 month after the start of intake.Results. The studied vitamin complexes showed good clinical tolerance in all children, including those with a history of allergic reactions to vitamin-mineral complexes. Evaluation of the efficacy of the vitamin complex in the 2nd group showed an improved provision, especially in children who had a deep deficiency of vitamins C (10%) and B6 (22%). At the same time, the excretion of vitamin B6 metabolite increased by 42.2%.Conclusion. The study showed the effective absorption of the studied vitamins and the good tolerability of the used vitamin complexes, including children with a history of allergic reactions to vitamin-mineral complexes